Publications

Xia YJ, Wang XY, Guo MS, Wu JH, Gao J, Dong TTX, Tsim KWK (2024): The activation of inflammatory response in the brain is potentiated by overexpressing acetylcholinesterase in myeloid lineage of transgenic mice. J Neurochem.


Xia YJ, Wang X, Lin S, Dong TTX, Tsim KWK (2024): Berberine and palmatine, acting as allosteric potential ligands of α7 nAChR, synergistically regulate inflammation and phagocytosis of microglial cells. FASEB J 38: e70094. doi: 10.1096/fj.202302538RRRR.


Yuen GKW, Kong I, Gao AX, Wu KQ, Lai QWS, Cheng EHC, Xia YJ, Guo MSS, Leung KW, Ho JYM, Chu CT, Tsim KWK (2024): The UV-induced release of acetylcholine plays role in regulating hair growth: signaling mediated by muscarinic acetylcholine receptor in dermal papilla cells. eLife.


Guo GX, Qiu YH, Liu Y, Yu LL, Zhang XY, Tsim KWK, Qin QW, Hu, WW (2024): Fucoxanthin attenuates angiogenesis by blocking VEGFR2-mediated signaling pathway through binding vascular endothelial growth factor. J Agric Food Chem 72:21610-21623.


Guo MSS, Wu QY, Xia YG, Wu JH, Wang XY, Yuen GKW, Dong TTX, Gao J, Tsim KWK (2024): Cholinergic signaling mediated by muscarinic receptors triggers the ultraviolet-induced release of melanosome in cultured melanoma cells. Pigment Cell Melanoma Res doi: 10.1111/pcmr.13201.


Liu Y, Liang JM, Guo GX, Qiu YH, Yu LL, Tsim KWK, Qin QW, Chan GK, Hu WH (2024): Screening of herbal extracts binding with vascular endothelial growth factor by applying HerboChip platform. Chin Med 19:122. doi:10.1186/s13020-024-00987-x.


Kong I, Yuen GKW, Wu QY, Guo MSS, Dong TTX, Tsim KWK (2024): Acetylcholine regulates the melanogenesis of retinal pigment epithelia cells via a cAMP-dependent pathway: a nonneuronal function of cholinergic system in retina. Heliyon 10: e36207.


Ng CWW, Yan WH, Xia YT, Tsim KWK, To JCT (2024): Plant growth-promoting rhizobacteria enhance active ingredient accumulation in medicinal plant P. heterophylla at eCO2 and are associated with indigenous microbial community. Front Microbiol 15:1426893.


Yang, MX, Yan CS, Ospondpant D, Wang, LS, Lin SY, Tang WL, Xia YJ, Dong TTX, Tong P, Xu Q, Tsim KWK (2024): Unveiling the therapeutic potential of Lobaria extract and its depsides/depsidones in combatting Aβ42 peptides aggregation and neurotoxicity in Alzheimer’s disease. Frontiers in Pharmacology 15: 1426569.


Li Z, Li CG, Chen BZ, Li B, Huang G, Huang YH, Hou YJ, Zhong PJ, Jin JW, Li DL, Tsim KWK, Gan LH, Chen WH, Wu RH (2024): Parabacteroides goldsteinii, enriched by Pericarpium Citri Reticulatae ‘Chachiensis’, polysaccharides improve colitis via the inhibition of lipopolysaccharide-involved PI3K-Akt signaling pathway. Int J Biol Macromol 277:133726.


Yuen GKW, Dong TTX, Tsim KWK (2024): Sophoricoside, a genistein glycoside from Fructus Sophorae, promotes hair growth via activation of M4 muscarinic AChR in dermal papilla cells. Journal of Ethnopharmacol 334:118585.


Ye L, Chen HD, Wang J, Tsim KWK, Wang YR, Shen X, Lei HT, Liu YL (2024): Aflatoxin B1-induced liver pyroptosis is mediated by disturbing the gut microbial metabolites: the roles of pipecolic acid and norepinephrine. Journal of Hazardous Materials 474:134822.


Wu QY, Xia YG, Guo SS, Au TY, Yuen GKW, Kong I, Wang ZQ, Lin YY, Dong TTX, Tsim KWK (2024): Acetylcholinesterase is regulated by exposure of ultraviolet B in skin keratinocytes: a potential inducer of cholinergic urticaria. FASEB J 38: e23641.


Ospondpant D, Lai QWS, Dong TTX, Tsim KWK (2024): Synergy of botanical drug extracts from Dracaena cochinchinensis stemwood and Ardisia elliptica fruit in multifunctional effects on neuroprotection and anti-inflammation. Frontiers in Pharmacology 15:1399549.


Lin SY, Wang XY, Tang RWL, Leung KW, Dong TTX, Webb SE, Miller AL, Tsim KWK (2024): The extracts of Evodiae Fructus and Stephaniae Tetrandrae Radix show synergy in blocking the entry of SARS-CoV-2. J Altern Complement Integr Med 10: 478.


Gong GW, Ganesan K, Zheng YZ, Xiao J, Dong TTX, Tsim KWK (2024): Nepetin attenuates atopic dermatitis in HaCaT cells and BALB/c mice through MyD88-MKK3/6-Akt signaling. Curr Med Chem doi: 10.2174/0109298673244967231101114033.


Tuohongerbieke A, Wang HY, Wu JH, Wang ZQ, Dong TTX, Huang YM, Zhu DQ, Sun DM, Tsim KWK (2024): Xiao Cheng Qi decoction, an ancient Chinese herbal mixture, relieves loperamide-induced slow transit constipation in mice: a mechanistic action mediated by gut microbiota. Pharmaceuticals 17:153


Yu LL, Guo GX, Qiu YH, Liu Y, Wang SY, Zhang XY, Tsim KWK, Qin QW, WH Hu (2024): Laminaria japonica extract inhibits VEGF-induced angiogenesis via binding with VEGF and regulation of VEGFR2 signaling pathway. Journal of Functional Foods 113:106024


Gao AX, Xia TC, Yuen GKW, Wu KQY, Dong TTX, Tsim KWK (2024): Luteolin, a common flavone in vegetables, acts as a hormetin processing neurotrophic function: signaling mediated by inducing mitochondrial stress. Food Science and Human Wellness 14: doi.org/10.26599/FSHW.2024.9250035


Wu JH, Zhang HL, Guo SS, Xia YJ, Li X, Dong TTX, Zhu Y, Tsim KWK (2023): Acori Tatarinowii Rhizoma prevents the fluoxetine-induced multiple-drug resistance of Escherichia coli against antibiotics. Phytomedicine 123:155232


Peng ZT, Xia YJ, Yashiro T, Gao X, Dong TTX, Tsim KWK, Wang HY (2023): Novel phenylpropanoids and isoflavone glycoside are isolated and identified from the carob pods (Ceratonia siliqua L.). Natural Product Research 37: 3395-3401.